GlossaryEN1 min readUpdated: Jun 25, 2026
Low-Temperature Cold Chain Storage
A pharmaceutical manufacturer ships an active ingredient: if it briefly exceeds the permitted temperature threshold, the entire batch is lost.
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Source: https://www.who.int/teams/immunization-vaccines-and-biologicals/essential-programme-on-immunization/cold-chain
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Logistics Concept
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Definition & Explanation
A pharmaceutical manufacturer ships an active ingredient: if it briefly exceeds the permitted temperature threshold, the entire batch is lost. Low-temperature cold chain storage refers to the controlled storage and transport of temperature-sensitive goods within defined cold zones – typically –20 °C to +8 °C – using certified refrigerated warehouses and conditioned transport containers. It applies primarily to pharmaceuticals, vaccines, blood products, and deep-frozen foods. Continuous temperature monitoring and documented records are regulatory requirements across most jurisdictions, not optional quality measures. Unlike standard refrigerated logistics (2 °C to 8 °C), deep-freeze operations require additional equipment such as dry ice or cryogenic systems and impose stricter obligations on forwarders, warehouses, and consignees.
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